Australian developer Straight Right who are handling the Wii U version of Mass Effect 3 have confirmed that Mass Effect will will run at 720p. News broke yesterday from Nintendo Power stating that the game will run at 1080p, but this information appears to be incorrect.
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Source:
http://mynintendonews.com/2012/08/31/mass-effect-3-wii-u-wont-run-at-1080p/